Commentary (Pendergrass/Griffin): What the Physician Needs to Know About Lynch Syndrome: An Update
نویسنده
چکیده
Dr. Henry Lynch was one of the first to recognize the existence of hereditary nonpolyposis colorectal cancer (HNPCC). While a relatively small percentage of families have this cancer predisposition syndrome, identification of individuals at risk is now standard of care and includes the potential for the prevention of colorectal cancer. Dr. Lynch and Jane Lynch have written a guide highlighting key points for physicians regarding the diagnosis, surveillance, and management of this disorder. Several aspects of clinical care mentioned in the article are expanded upon here.
منابع مشابه
Commentary (Gruber et al)—What the Physician Needs to Know About Lynch Syndrome: An Update
In many respects, Lynch syndrome serves as the paradigm of cancer genetic syndromes. It is relatively common and accounts for approximately 3% to 5% of colorectal cancer cases. The genetic basis is clearly understood, and genetic testing is clinically available and routinely incorporated into clinical practice. Furthermore, the diagnosis has a profound impact on the management of individuals at...
متن کاملWhat the physician needs to know about Lynch syndrome: an update.
The Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), is the most common form of hereditary colorectal cancer (CRC), accounting for 2% to 7% of all CRC cases. The next most common hereditary CRC syndrome is familial adenomatous polyposis (FAP), which accounts for less than 1% of all CRC. Lynch syndrome is of crucial clinical importance due to the fact that it predicts the life...
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More than two decades ago, Henry T. Lynch reported a hereditary non polyposis colorectal cancer (HNPCC) which is seen in some families with dominant mode of inheritance, also know as Lynch Syndrome type I and II. This form to hereditary colorectal cancer has an early age of onset (Less than 45 years) with predominantly proximal colonic involvement (type I) and can also be associated with extrac...
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